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Greenland Mines Ltd Announces Australian Patent Grant for Klotho-Based Gene Therapy for Neuromuscular Diseases

Greenland Mines Ltd announced a new Australian patent for gene therapy targeting neuromuscular diseases via Klotho protein.

Quiver AI Summary

Greenland Mines Ltd announced the granting of Australian Patent No. 2023252508 for its gene therapy technology aimed at treating neuromuscular diseases by expressing the Klotho protein. This innovation, developed by researchers from Universitat Autònoma de Barcelona, covers methods to deliver human Klotho protein to muscle and neuronal cells, utilizing various cellular delivery systems. CEO Dr. Joseph Sinkule emphasized the significance of this patent in advancing their KLTO-202 therapy for ALS and similar conditions, which could redefine treatment approaches for motor neuron diseases. Greenland Mines is a dual-division company with interests in mining and biotechnology, with a strategy that aims to leverage its intellectual property in the Klotho therapeutic platform.

Potential Positives

  • Greenland Mines Ltd has been granted an Australian patent for a groundbreaking gene therapy technology to treat neuromuscular diseases, which strengthens its intellectual property portfolio.
  • The patented technology specifically relates to a novel approach using Klotho protein in gene therapy, highlighting the potential for innovative treatments in addressing serious conditions like ALS.
  • This patent represents a significant advancement in the Company’s biotechnology platform, emphasizing its commitment to developing new therapeutic solutions and enhancing shareholder value.

Potential Negatives

  • The press release highlights reliance on forward-looking statements, which may create uncertainty about the Company's ability to achieve its business plans and projections.
  • The Company’s statement regarding the potential of its Klotho-based therapeutic platform may raise expectations that could lead to dissatisfaction if results do not meet investor hopes.
  • The focus on patents may distract from immediate operational challenges faced in the mining division, which could affect overall company performance.

FAQ

What is the significance of Australian Patent No. 2023252508?

The patent protects gene therapy technology for treating neuromuscular diseases using the human Klotho protein, enhancing Greenland Mines’ intellectual property.

How does Klotho protein relate to neuromuscular diseases?

Research indicates that Klotho plays a crucial role in neuronal health and may address underlying issues in conditions like ALS and muscle disorders.

Who invented the patented gene therapy technology?

The technology was developed by researchers at Universitat Autònoma de Barcelona and affiliated institutions, licensed by Greenland Mines’ Biotech Division.

What therapeutic applications does KLTO-202 target?

KLTO-202 primarily targets ALS and other neuromuscular diseases, focusing on restoring Klotho expression to improve motor function.

How does Greenland Mines integrate its projects?

The company combines mining and biotech operations, aiming to create a multi-asset platform linking rare earth resources with clinical advancements.

Disclaimer: This is an AI-generated summary of a press release distributed by GlobeNewswire. The model used to summarize this release may make mistakes. See the full release here.


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$GRML Insider Trading Activity

GRML Insider Trades

$GRML insiders have traded $GRML stock on the open market 1 times in the past 6 months. Of those trades, 0 have been purchases and 1 have been sales.

Here’s a breakdown of recent trading of $GRML stock by insiders over the last 6 months:

  • RIAD HUSSEIN EL-DADA sold 175,000 shares for an estimated $40,547

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Here are some of the largest recent moves:

  • METEORA CAPITAL, LLC added 5,373,748 shares (+76767828.6%) to their portfolio in Q1 2026, for an estimated $1,773,336
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Full Release

NEW YORK, July 10, 2026 (GLOBE NEWSWIRE) -- via IBN -- Greenland Mines Ltd (Nasdaq: GRML) ("Greenland Mines" or the "Company") today announced that IP Australia has granted Australian Patent No. 2023252508, entitled "Treatment of Neuromuscular Diseases via Gene Therapy that Expresses Klotho Protein," covering technology exclusively licensed by the Company's Biotech Division. The patented technology was invented by researchers at Universitat Autònoma de Barcelona and collaborating institutions.

The issued patent protects the use of a human gene therapy using a muscle-cell specific promoter operatively linked to a nucleic acid gene sequence encoding the human Klotho s-KL protein for treating motor impairment. The patent includes claims covering neuronal cells and induced pluripotent stem cells (iPSC) containing the muscle-cell specific promoter and s-KL nucleic acid gene sequence, as well as other cellular delivery systems such as adeno-associated viral vectors (AAV) and non-viral vectors with muscle-cell and/or motor neuron-cell tropism.

The patent further expands the Company's growing global intellectual property estate supporting its Klotho-based therapeutic platform.

Dr. Joseph Sinkule, the Company’s founder and CEO, stated: " Over the past three years, we have advanced KLTO-202 around a simple but compelling scientific premise—that restoring or supplementing human Klotho expression may help address the underlying biology of ALS and other debilitating neuromuscular diseases. A growing body of research has demonstrated the critical role Klotho plays in neuronal health, muscle function, aging, and cellular resilience. This patent strengthens the intellectual property protecting our approach, reinforces the long-term value of our biotechnology platform, and provides an important foundation as we continue advancing KLTO-202 toward clinical development. We believe Klotho has the potential to represent an entirely new therapeutic paradigm for treating motor neuron diseases. "

Neuromuscular diseases include ALS, spinal muscular atrophy (SMA), Charcot-Marie-Tooth disease, multiple sclerosis, muscular dystrophies, peripheral neuropathies, traumatic nerve injury, age-related muscular atrophy, and numerous other neuromuscular and motor neuron disorders.

About Greenland Mines Ltd

Greenland Mines Ltd is a Nasdaq-listed company with two operating divisions: (1) Mining, focused on the exploration and development of the Skaergaard Project in southeast Greenland and, subject to closing of the previously announced transaction, the Sarfartoq neodymium-praseodymium (Nd-Pr) rare earths project in southwest Greenland; and (2) Biotech, including Klotho's KLTO???202 primary indication for ALS. The Company’s strategy is centered on building a multi-asset platform with exposure to rare earth magnet materials, precious metals, and select midstream processing opportunities, while advancing its broader North Atlantic Critical Metals Corridor vision linking Greenland resources with allied downstream jurisdictions and industrial infrastructure.

Forward???Looking Statements

This press release contains forward-looking statements. These statements are made under the "safe harbor" provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements generally are identified by the words "believe," "project," "expect," "anticipate," "estimate," "intend," "strategy," "future," "opportunity," "plan," "may," "should," "will," "would," "will be," "will continue," "will likely result," and similar expressions. Without limiting the generality of the foregoing, the forward-looking statements in this press release include descriptions of the Company's future commercial operations. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, such as the Company's inability to implement its business plans, identify and realize additional opportunities, or meet or exceed its financial projections and changes in the regulatory or competitive environment in which the Company operates. You should carefully consider the foregoing factors and the other risks and uncertainties described in the documents filed or to be filed by the Company with the U.S. Securities and Exchange Commission (the "SEC") from time to time, which could cause actual events and results to differ materially from those contained in the forward-looking statements. All information provided herein is as of the date of this press release, and the Company undertakes no obligation to update any forward-looking statement, except as required under applicable law.

Investor Contact and Corporate Communications:
ir@greenlandmines.com
Website:
www.greenlandmines.com


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